Endocrine Abstracts

Introduction: Hypertension is a very common chronic disease worldwide. Its imbalance is one of the main causes of cardiovascular and neurodegenerative complications.Patients and Methods: We collected data from hypertensive patients who voluntarily presented for screening on both diabetes and hypertension screening days.Poor blood pressure control was defined as systolic blood pressure (SBP) greater than or equal to 140 mmHg and/or diastolic blood pressur...

Introduction: Thyrotropin-secreting pituitary adenomas represent less than 1% of all pituitary adenomas. Usually, patients present mild or moderate signs of hyperthyroidism and Hormonal evaluation shows increased free thyroid hormone concentration with detectable, normal or increased serum thyrotropin (TSH) level. Herein we report three cases of thyrotropin adenomas with particular clinical and biological features.Observations: Three patients, aged 25 38...

IntroductionThe thresholds of late night salivary cortisol (LNSC) vary widely among studies due to differences in assay methodologies and in control groups. We aimed to verify the analytical performance of the LNSC by electrochimiluminescence assay (ECLIA) and to establish cut-off values of LNSC for the screening of Cushing’s syndrome (CS).MethodsPatients with suspected CS underwent screening tests inclu...

IntroductionUncontrolled hyperglycemia of diabetes is a common cause of renal failure and diabetic nephropathy, which is also called diabetic kidney disease (DKD). Despite improvements in the management of type 1 diabetes (T1D), progression of diabetic nephropathy remains unpredictable and associated with high morbidity and mortality. The objective of this study is to assess the prevalence and risk factors for diabetic kidney disease among adults-onset T...

IntroductionNon-functioning pituitary adenomas (NFPA) present approximately 15% to 30% of all pituitary adenomas. They are most commonly misdiagnosed, until they are large enough to lead to mass effect and hypopituitrasm. The present study was carried out with the aim of studying the clinical and biological characteristics of patients who are followed for NFA.Patients and methodsThis is a retrospective study ...

Introduction: Addison disease is associated with high risk of fractures and low bone mineral density. Causes are complex, including supraphysiologic glucocorticoid replacement therapy and concomitant autoimmune disorders. The aim of our study is to assess the influence of glucorticoid replacement therapy on bone mineral density in patients with Addison disease.Patients and methods: Descriptive and analytical cross- sectional study including 50 patients w...

Introduction: In adults with Addison disease, over glucocorticoid replacement therapy is associated with an increased morbidity and decreased life expectancy, related to low bone mineral density and cardiometabolic outcomes. The aim of our study was to assess the prevalence of carbohydrate metabolism disorders in patients with Addison disease and identify its predictive factors.Patients and methods: A cross sectional study including 50 patients diagnosed...

Introduction: Long-term glucocorticoid replacement therapy in patients with Addison disease has been linked to an increased cardiovascular risk and consequent mortality. Our objective was to determine the frequency of dyslipidemia in patients with Addison disease and its potential predictive factors.Patients and methods: This was a cross-sectional study, performed in the department of endocrinology in Hedi Chaker hospital –Sfax –Tunisia. Fifty ...

Introduction: Inadequate glucocorticoid replacement therapy in Addison disease leads to an increased risk of both cardiovascular disease and metabolic syndrome. The metabolic effects of long-life corticosteroid exposure are due to physiological mechanisms that are associated with carbohydrate metabolism disorder, dyslipidemia and insulin resistance. In this study, we aimed to determine the prevalence and predictive factors of metabolic syndrome in patients with Addison disease...

Introduction: Conventional glucocorticoid replacement therapy has been suggested to increase morbidity in patients with Addison disease and fail to restore their quality of life (QOL). The aim of our study was to assess QOL in patients with Addison disease and to identify factors that determine their QOL.Patients and methods: This cross-sectional study was carried out at the department of Endocrinology in HediChaker hospital-Sfax –Tunisia, from Marc...